Symptoms of Mesothelioma

Mesothelioma Symptoms: Early Signs, Types & What to Watch For

Updated: June 20, 2025 • Medical Reviewer: Dr. Alicia Martinez, MD

Mesothelioma can present differently in the lungs, abdomen, heart, and testes.

Mesothelioma is a rare but aggressive cancer most often caused by inhaling or ingesting asbestos fibers. Recognizing early mesothelioma symptoms — even the subtle ones — is the best way to improve your treatment options and outlook.

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Quick Navigation

1. Pleural (Lung) Mesothelioma
2. Peritoneal (Abdominal) Mesothelioma
3. Pericardial & Testicular Types
4. Why These Symptoms Occur
5. When to Seek Medical Advice
6. Prevention & Risk Reduction
7. FAQ

Pleural (Lung) Mesothelioma Symptoms

Pleural mesothelioma accounts for roughly 80 percent of all cases in the United States. Tumors form in the lining of the lungs (pleura) and may cause:

• Persistent chest pain or tightness
• Shortness of breath (dyspnea)
• Chronic dry cough
• Unexplained weight loss & fatigue
• Hoarseness or difficulty swallowing (dysphagia) in advanced stages

Important: Fluid buildup around the lungs (pleural effusion) is the primary driver of shortness of breath and chest pain. Removing this fluid often provides temporary relief.

Peritoneal (Abdominal) Mesothelioma Symptoms

Peritoneal mesothelioma develops in the lining of the abdominal cavity (peritoneum). Common warning signs include:

• Abdominal swelling caused by fluid (ascites)
• Persistent abdominal pain or cramps
• Nausea or indigestion
• Changes in bowel habits (constipation or diarrhea)
• Loss of appetite and unintended weight loss

Less Common Types: Pericardial & Testicular

Pericardial Mesothelioma (Heart Lining)

This form affects the sac surrounding the heart (pericardium). Symptoms often mimic other heart conditions:

• Chest pain unrelated to exertion
• Irregular heartbeat or palpitations
• Difficulty breathing when lying down

Testicular Mesothelioma (Tunica Vaginalis)

Extremely rare; primary signs include:

• Swelling or a painless lump in the scrotum
• Groin discomfort or heaviness

Why Do These Symptoms Occur?

Mesothelioma tumors irritate the thin membranes that line vital organs. As tumors grow, they may:

• Produce excess fluid (effusion) that compresses organs
• Cause inflammation and thickening of the lining
• Interfere with normal organ function (e.g., lung expansion)

Because symptoms typically take 20–50 years to appear after asbestos exposure, many patients are diagnosed at advanced stages. Early awareness is key.

When Should You See a Doctor?

Consult a healthcare professional if you experience:

• Persistent chest or abdominal pain lasting >2 weeks
• Shortness of breath that worsens over time
• Sudden unexplained weight loss or fatigue
• History of occupational asbestos exposure

Early imaging (X‑ray or CT) and a biopsy remain the gold‑standard for diagnosis.

Prevention & Risk Reduction

While past exposure cannot be reversed, you can reduce ongoing risk by:

1. Avoiding DIY asbestos removal; hire certified professionals.
2. Following OSHA safety guidelines if you work in construction, shipyards, or older factories.
3. Never sanding or drilling materials that may contain asbestos (e.g., popcorn ceilings).
4. Using proper respirators and protective equipment.

EPA asbestos safety resources ›

Frequently Asked Questions

What are the first symptoms of mesothelioma?

Persistent chest pain, shortness of breath, abdominal swelling, and unexplained weight loss are the most common early signs.

How long after asbestos exposure do symptoms appear?

Typically 20–50 years; however, latency periods as short as 15 years have been reported.

Is mesothelioma curable?

There is currently no cure, but surgery, chemotherapy, radiation, and immunotherapy can improve survival and quality of life.

Disclaimer: This content is for educational purposes only and not a substitute for professional medical advice. Always consult a qualified physician for diagnosis and treatment.